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A synthetic prodrug of 1,25-dihydroxy vitamin D2; used to suppress the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism; stimulates bone growth; inhibits the growth of certain blastomas and prostate cancer cells
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Nudifloramide-d3 (2PY-d3) is a deuterium labeled Nudifloramide. It is an end product of nicotinamide-adenine dinucleotide (NAD) degradation and significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro. Deuteration, the incorporation of stable heavy isotopes, allows it to be used as a tracer during drug development, affecting pharmacokinetic and metabolic profiles of drugs.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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Melatonin-d3 is a deuterium-labeled form of Melatonin, a hormone produced by the pineal gland. Melatonin activates melatonin receptors and is known for its role in sleep, as well as its significant antioxidative and anti-inflammatory properties. It has been identified as a novel selective ATF-6 inhibitor and can induce apoptosis in human hepatoma cells by downregulating COX-2. Additionally, Melatonin has been shown to attenuate palmitic acid-induced mouse granulosa cell apoptosis through endoplasmic reticulum stress.
Deuterium labeled
Tracer
Internal standard for quantitative analysis
Pharmacokinetic studies
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D3/5-HT receptor modulator-1 (compound 5i) is a selective dopamine D3 receptor and 5-HT2A receptor antagonist and a partial 5-HT1A receptor agonist. It has a low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels, and presents an atypical antipsychotic profile.
Selective dopamine D3 receptor and 5-HT2A receptor antagonist.
Partial 5-HT1A receptor agonist.
Shows Ki values of 4.5 nM (D3), 11.9 nM (5-HT2A), and 15.3 nM (5-HT2A).
Low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels.
Atypical antipsychotic profile.
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(R)-Vitamin D2 is an isomer of Vitamin D2 (HY-76542) and can be utilized as an experimental control. Vitamin D2 (Ergocalciferol), derived from plant sources or dietary supplements, can be employed as a Vitamin D supplement. This product is exclusively for research purposes and is not intended for patient use.
Isomer of vitamin D2
Can be used as an experimental control
Derived from plant sources or dietary supplements
Can be employed as a vitamin D supplement
Exclusively for research purposes
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More